Rule : 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (FOLK)

Rule Description

ID	NRULE_0159
Rule name	FOLK
Created	2013-03-12
Protein name	Protein name Full 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EC EC 2.7.6.3 Synonym Full 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase Short PPPK HPPK
Gene name	folK
Rule Trigger	PFAM; PF01288; hit=1
Cross Reference	Gene Ontology GO GO:0003848, F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity, IDA:EcoCyc GO:0005524, F:ATP binding, IEA:UniProtKB-KW GO:0016301, F:kinase activity, IEA:UniProtKB-KW GO:0000287, F:magnesium ion binding, IDA:EcoCyc GO:0046656, P:folic acid biosynthetic process, IEA:UniProtKB-KW GO:0046654, P:tetrahydrofolate biosynthetic process, IEA:UniProtKB-UniPathway Phylogenomic databases eggNOG COG0801, - HOGENOM HOG000217741, - KO K00950, - ProtClustDB PRK10239, - Enzyme and pathway databases BioCyc MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-MONOMER, - UniPathway UPA00077, UER00155 Family and domain databases InterPro IPR000550, Hppk Pfam PF01288, HPPK, 1 TIGRFAMs TIGR01498, folK, 1 PROSITE PS00794, HPPK, 1
Feature	Not assigned
General annotation	Catalytic activity ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6- yl)methyl diphosphate Pathway Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2- amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4 Subunit structure Monomer Sequence similarities Belongs to the HPPK family
Reference	P26281 Escherichia coli (strain K12). 1325970 Cloning, sequence analysis, and overexpression of Escherichia coli folK, the gene coding for 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (J Bacteriol. 1992) 8202364 Systematic sequencing of the Escherichia coli genome: analysis of the 2.4-4.1 min (110,917-193,643 bp) region. (Nucleic Acids Res. 1994) 9278503 The complete genome sequence of Escherichia coli K-12. (Science. 1997) 16738553 Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006)

Related Function

Function name
Folate biosynthesis

CDS


Scientific name	NBRC No.	CDS	Product name
Acaricomes phytoseiuli	107788	C501_03665	hypothetical protein
Acaryochloris marina	102967	AM1_1969	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Acetobacter aceti	14818	AaceN1_010100010763	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Acetobacter pasteurianus	105190	APA32_06430	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HppK
Acetobacter pasteurianus	101655	APT_0066	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase HppK
Acetobacter tropicalis	101654	ATPR_0442	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase HppK
Acidimicrobium ferrooxidans	103882	Afer_1909	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Acidiphilium multivorum	100883	ACMV_06030	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Acidithiobacillus ferrooxidans		Lferr_1449	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Acidobacterium capsulatum	15755	ACP_2315	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Acinetobacter radioresistens	102413	ACRAD_04_00410	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Acinetobacter radioresistens	102413	ACRAD_21_00190	putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Acinetobacter sp.	100985	ACT4_006_01180	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Acinetobacter sp.	100985	ACT4_025_01180	putative 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Actinoalloteichus cyanogriseus	14455	G443_06_00360	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Actinoalloteichus spitiensis	102582	ACTIDRAF_08715	hypothetical protein
Actinomadura atramentaria	14695	G339_15280	hypothetical protein
Actinoplanes missouriensis	102363	AMIS_77860	putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Actinopolyspora iraqiensis	103187	ACTIR_001_00020	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Actinosynnema mirum	14064	Amir_0317	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Aerococcus viridans	12219	HMPREF0061_0619	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Alicyclobacillus acidocaldarius subsp. acidocaldarius	15652	Aaci_0206	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Alloiococcus otitis	15545	HMPREF9698_01532	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Alteromonas macleodii	102226	MASE_02980	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Alteromonas macleodii	102226	MASE_17345	7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase
Amycolatopsis azurea	14573	C791_0697	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Amycolatopsis mediterranei	13415	RAM_44865	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Anoxybacillus flavithermus	15317	Aflv_0071	7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Aquifex aeolicus		aq_162	folate biosynthesis 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Aquimarina agarilytica	107695	AagaZ_020100007220	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Arcanobacterium haemolyticum	15585	Arch_0254	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Ardenticatena maritima		ARMA_1915	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Arthrobacter globiformis	12137	ARGLB_032_00370	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Atopobium rimae	15546	ATORI0001_1446	dihydropteroate synthase
Austwickia chelonae	105200	AUCHE_03_01700	putative dihydroneopterin aldolase
Azorhizobium caulinodans	14845	AZC_1217	8-dihydro-6-hydroxymethylpterin- pyrophosphokinase
Bacillus amyloliquefaciens	15535	BAMF_0079	7, 8-dihydro-6-hydroxymethylpterinpyrophosphokinase
Bacillus atrophaeus	13721	BATRMS_24_00560	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Bacillus cereus	15305	BC_0081	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Bacillus licheniformis	12200	BL05004	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase
Bacillus licheniformis	12195	BLi00095	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK
Bacillus mojavensis	15718	GYU_04_02800	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Bacillus mycoides	101228	bmyco0001_610	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Bacillus pseudomycoides	101232	bpmyx0001_610	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Bacillus psychrosaccharolyticus	101233	WYK_203_00040	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Bacillus pumilus	12092	BAT_4070	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Bacillus subtilis	3134	BSU6633_00670	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Bacillus subtilis subsp. subtilis	13719	BSU00790	7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase
Bacteroides vulgatus	14291	BVU_1174	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine
Bacteroides vulgatus	14291	BVU_3329	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Balneola vulgaris		B155_RS0112105	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Bergeyella zoohelcum	16014	HMPREF9699_01904	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Beutenbergia cavernae	16432	Bcav_0705	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Bradyrhizobium diazoefficiens	14792	bll3057	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Brevibacillus brevis	100599	BBR47_01780	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Brevibacterium linens	12170	BlinB_010200013913	Dihydroneopterin aldolase
Brevundimonas diminuta	12697	BDIM_17850	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Brevundimonas subvibrioides	16000	Bresu_2510	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Caldanaerobacter subterraneus subsp. tengcongensis	100824	TTE2369	7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Caldilinea aerophila	104270	CLDAP_28280	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Caldisericum exile	104410	CSE_04210	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Calditerrivibrio nitroreducens	101217	Calni_0874	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Candidatus Solibacter usitatus		Acid_0958	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Catenulispora acidiphila	102108	Caci_8420	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Caulobacter segnis	15250	Cseg_2655	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Cellulomonas fimi	15513	Celf_0562	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Cellulomonas flavigena	3775	Cfla_0630	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Cellulophaga lytica	14961	Celly_1930	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Chitinispirillum alkaliphilum		CHISP_2105	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Chitinivibrio alkaliphilus		CALK_1878	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Chitinophaga pinensis	15968	Cpin_5842	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Chlamydia trachomatis		CTL0877	2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne pyrophosphokinase
Chloracidobacterium thermophilum B		Cabther_A1724	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Chlorobaculum tepidum	103806	CT1938	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine-pyrophosphokinase
Chlorobium limicola	103803	Clim_2141	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Chromobacterium violaceum	12614	CV_1633	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine
Chryseobacterium gleum	15054	HMPREF0204_11957	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Chrysiogenes arsenatis		P304_RS15210	hypothetical protein
Chthoniobacter flavus		CfE428DRAFT_0874	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Chthonomonas calidirosea		CCALI_02815	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase
Clostridium acetobutylicum	13948	CA_C2927	dihydroneopterin aldolase/7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase fusion protein
Clostridium clariflavum	101661	Clocl_4041	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Clostridium kluyveri	12016	CKR_0868	hypothetical protein
Clostridium thermocellum	103400	Cthe_2583	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Conexibacter woesei	100937	Cwoe_1676	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Congregibacter litoralis	104960	KT71_02232	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Congregibacter litoralis	104960	KT71_08054	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Coraliomargarita akajimensis		Caka_2397	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Corynebacterium ammoniagenes	12612	HMPREF0281_01492	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Corynebacterium callunae	15359	H924_11285	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Corynebacterium efficiens	100395	CE2538	putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Corynebacterium glutamicum	12168	Cgl2692	7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase
Corynebacterium glutamicum	12153	KIQ_12265	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Corynebacterium matruchotii	15360	HMPREF0299_7533	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Corynebacterium striatum	15291	HMPREF0308_2215	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Corynebacterium terpenotabidum	14764	A606_01965	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Cupriavidus metallidurans	102507	Rmet_2915	2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase
Cystobacter fuscus	100088	D187_000420	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Cytophaga hutchinsonii	15051	CHU_2468	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase (7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase)
Deferribacter desulfuricans	101012	DEFDS_1511	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Dehalococcoides mccartyi		DehaBAV1_1350	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Deinococcus proteolyticus	101906	Deipr_1894	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Desulfovibrio magneticus	104933	DMR_22000	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Desulfovibrio vulgaris subsp. vulgaris	104121	DVU_1656	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Dictyoglomus turgidum		Dtur_0617	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Edwardsiella tarda	105688	ET1_10_01220	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Elusimicrobium minutum		Emin_0762	2-Amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Endomicrobium proavitum		Epro_0752	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Enterobacter aerogenes	13534	EAE_11500	2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase
Enterobacter cloacae subsp. cloacae	13535	ECL_00946	2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase
Enterobacter hormaechei	105718	HMPREF9086_1687	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Enterococcus haemoperoxidus	100709	I583_00580	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Enterococcus pallens	100697	I588_03235	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Escherichia coli	3972	EcolC_3517	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Escherichia coli	13500	WFL_00685	2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase
Escherichia coli	12713	Y75_0139	2-amino-4-hydroxy-6- hydroxymethyldihyropteridine pyrophosphokinase
Escherichia fergusonii	102419	EFER_0165	2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase
Escherichia hermannii	105704	EH105704_09_00550	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Fibrobacter succinogenes		Fisuc_2429	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Fimbriimonas ginsengisoli		OP10G_1751	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Finegoldia magna		FMG_0880	bifunctional aldolase-pyrophosphokinase
Fischerella sp.		PCC9339_RS0117600	hypothetical protein
Flavobacterium johnsoniae	14942	Fjoh_1719	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Flexibacter litoralis	15988	Fleli_3332	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Fluviicola taffensis	106335	Fluta_2511	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Frateuria aurantia	3245	Fraau_2546	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Frateuria aurantia	3245	Fraau_2726	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Fusobacterium nucleatum subsp. Nucleatum		FN0072	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Geodermatophilus obscurus	13315	Gobs_0620	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Gloeobacter violaceus		glr2647	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Gluconacetobacter hansenii	14816	GXY_04619	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Gluconobacter frateurii	101659	GfraN1_010100000380	bifunctional folate synthesis protein
Gordonia aichiensis	108223	GOACH_01_01750	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia alkanivorans	16433	GOALK_015_00200	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia amarae	15530	GOAMR_72_00240	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia amicalis	100051	GOAMI_36_00160	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia araii	100433	GOARA_053_00140	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia bronchialis	16047	Gbro_4013	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Gordonia effusa	100432	GOEFS_076_00350	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia hirsuta	16056	GOHSU_61_00140	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia namibiensis	108229	GONAM_34_00280	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia otitidis	100426	GOOTI_012_00220	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia polyisoprenivorans	16320	GOPIP_077_01420	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia rhizosphera	16068	GORHZ_058_00110	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia rubripertincta	101908	GORBP_059_00500	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia sihwensis	108236	GSI01S_12_00130	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia soli	108243	GS4_11_03990	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia sputi	100414	GOSPT_103_00570	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Gordonia terrae	100016	GOTRE_054_00620	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Halobacillus halophilus	102448	HBHAL_1093	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase
Halomonas elongata	15536	HELO_3477	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase
Halomonas elongata	15536	HELO_4127	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase
Herpetosiphon aurantiacus		Haur_4053	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Holophaga foetida		HOLFODRAFT_RS21495	hypothetical protein
Hylemonella gracilis	14920	HGR_01422	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Hyphomonas neptunium	14232	HNE_2364	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Ignavibacterium album	101810	IALB_2376	7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase
Intrasporangium calvum	12989	Intca_0603	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Jonesia denitrificans	15587	Jden_2101	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Kineococcus radiotolerans	101839	Krad_0542	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Kineosphaera limosa	100340	KILIM_093_00060	dihydroneopterin aldolase/2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Kitasatospora setae	14216	KSE_43890	putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Klebsiella pneumoniae	14438	KPR_1072
Klebsiella pneumoniae subsp. rhinoscleromatis	105682	HMPREF0484_4873	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Kocuria rhizophila	103217	KRH_19240	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Kordia algicida	100336	KAOT1_13322	deoxyguanosine kinase/deoxyadenosine kinase subunit
Kribbella flavida	14399	Kfla_6462	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Ktedonobacter racemifer		Krac_10276	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Kyrpidia tusciae	15312	Btus_0105	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Kytococcus sedentarius	15357	Ksed_24750	dihydroneopterin aldolase/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Labrenzia aggregata	16684	SIAM614_25382	6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Lactobacillus delbrueckii subsp. bulgaricus	13953	Ldb0247	2-Amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase / GTP cyclohydrolase I
Lactobacillus fermentum	15885	HMPREF0511_1710	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Lactobacillus fermentum	3956	LAF_1340	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Lactobacillus helveticus	15019	HMPREF0518_0257	GTP cyclohydrolase I
Lactobacillus hilgardii	15886	HMPREF0519_2227	GTP cyclohydrolase I
Lactobacillus plantarum subsp. plantarum	15891	HMPREF0531_12979	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Lactobacillus reuteri	15892	LAR_1212	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Leadbetterella byssophila	106382	Lbys_1116	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Lentisphaera araneosa		LNTAR_03539	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e pyrophosphokinase
Lentisphaera araneosa		LNTAR_11576	bifunctional folate synthesis protein
Leptospira interrogans		LA_3959	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Leuconostoc lactis	107866	EY7_1058_00030	Hydroxymethylpterin pyrophosphokinase
Limnochorda pilosa	110152	LIP_3123	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Magnetospirillum gryphiswaldense	15271	MGR_3197	7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK
Magnetospirillum magnetotacticum	15272	Magn03006785	COG0801: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Marinomonas mediterranea	103028	Marme_3608	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Mariprofundus ferrooxydans		SPV1_07209	7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK
Mariprofundus ferrooxydans		SPV1_09944	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Marivirga tractuosa	15989	Ftrac_1086	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Meiothermus silvanus	106475	Mesil_0349	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Methylacidiphilum infernorum		Minf_0340	7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Methylobacterium radiotolerans	15690	Mrad2831_0511	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Micrococcus luteus	3333	Mlut_01280	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Microlunatus phosphovorus	101784	MLP_48430	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Micromonospora aurantiaca	16155	Micau_5871	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Microscilla marina	16560	M23134_03218	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Mobilicoccus pelagius	104925	MOPEL_074_00710	dihydroneopterin aldolase/2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Myroides odoratus	14945	Myrod_2325	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Nakamurella multipartita	105858	Namu_0852	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Niastella koreensis	106392	Niako_0947	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Nitriliruptor alkaliphilus		NitalDRAFT_1538	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
Nitrosomonas europaea	14298	NE0070	7, 8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase
Nitrospina gracilis		NITGR_610044	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinediphosphokinase
Nocardiopsis dassonvillei	14626	Ndas_4974	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Nostoc sp.		asr2953	7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Oceanithermus profundus	100410	Ocepr_1873	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Ochrobactrum anthropi	15819	Oant_2117	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Ochrobactrum intermedium	15820	OINT_1001189	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Paenibacillus alvei	3343	PAV_2c06600	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK
Paenibacillus peoriae	15541	PpeoK3_010100024104	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Paenibacillus polymyxa	15309	PPT_00385	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Pedobacter heparinus	12017	Phep_3073	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Pedobacter saltans	100064	Pedsa_2103	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Pelobacter carbinolicus	103641	Pcar_0250	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Pelobacter propionicus	103807	Ppro_0296	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Phaeobacter gallaeciensis	16654	PGA1_c00990	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK
Phycisphaera mikurensis	102666	PSMK_13480	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Planctomyces brasiliensis	103401	Plabr_0779	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Prochlorococcus marinus subsp. marinus		Pro_0318	7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Propionibacterium acidipropionici	12425	PACID_28450	Putative hydroxymethyldihydropteridine pyrophosphokinase
Propionibacterium avidum	15671	HMPREF9153_1338	hydroxymethyldihydropteridine pyrophosphokinase
Proteus mirabilis	105697	HMPREF0693_3254	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Providencia alcalifaciens	105687	PROVALCAL_02383	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Pseudomonas putida	100650	PP_0393	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Pseudomonas putida	100650	PP_4698	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Pseudomonas stutzeri	14165	PSTAB_0613	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Pseudomonas stutzeri	14165	PSTAB_3342	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Rahnella aquatilis	105701	Rahaq2_3753	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Renibacterium salmoninarum	15589	RSal33209_3211	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Rhizobium etli	15573	RHE_CH02334	7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinas e protein
Rhizobium sp.	101917	NGR_c16580	putative 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Rhizobium tropici	15247	RTCIAT899_CH09995	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Rhodobacter capsulatus	16581	RCAP_rcc03319	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Rhodobacter sphaeroides	12203	RSP_1668	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Rhodococcus erythropolis	100887	RER_06290	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Rhodococcus opacus	108011	ROP_43270	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Roseobacter denitrificans	15277	RD1_1357	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Roseobacter litoralis	15278	RLO149_c034280	putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Rothia dentocariosa	12531	HMPREF0733_10712	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Rothia mucilaginosa	15673	ROTMU0001_1803	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Rubrobacter xylanophilus	100952	Rxyl_2183	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Saccharomonospora azurea	14651	SacazDRAFT_02324	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Saccharomonospora cyanea	14841	SaccyDRAFT_4693	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Saccharomonospora glauca	14831	SacglDRAFT_03951	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Saccharomonospora viridis	12207	Svir_35610	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Saccharopolyspora erythraea	13426	SACE_0400	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase
Saccharopolyspora spinosa	15153	SspiN1_010100021133	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Saccharothrix espanaensis	15066	BN6_03540	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase
Salinibacter ruber		SRU_0955	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Salinispora arenicola	105043	Q5S_3012_00030	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Salinispora tropica	105044	Strop_4295	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Sanguibacter keddieii	16158	Sked_32060	dihydroneopterin aldolase/2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Selenomonas ruminantium subsp. lactilytica	103574	SELR_27250	putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydrofolate reductase
Serratia odorifera	102598	HMPREF0758_2161	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Shimwellia blattae	105725	EB105725_11_00600	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Solitalea canadensis	15130	Solca_2261	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Sphingobacterium spiritivorum	14948	HMPREF0766_11596	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Sphingobium japonicum	101211	SJA_C1-21910	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Sphingobium sp.	103272	SLG_11020	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Sphingomonas echinoides	15742	SechA1_010100012397	7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Sphingomonas wittichii	105917	Swit_1215	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Sporichthya polymorpha	12702	Spopo_30_19760	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e diphosphokinase
Stackebrandtia nassauensis	102104	Snas_6216	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Staphylococcus epidermidis	12993	SE_2267	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Staphylococcus saprophyticus subsp. saprophyticus	102446	SSP2240	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Starkeya novella	14993	Snov_0657	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Streptococcus equinus	12553	HMPREF0819_0599	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Streptococcus mitis	106071	SM12261_0580	bifunctional folate synthesis protein
Streptomyces avermitilis	14893	SAV4669	putative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Streptomyces cattleya	14057	SCAT_2646	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase
Streptomyces clavuligerus	13307	SCLAV_2410	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Streptomyces ghanaensis	15414	SSFG_03189	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Streptomyces mobaraensis	13819	H340_05549	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Streptomyces pristinaespiralis	13074	SSDG_06476	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Streptomyces purpureus	13925	STRPU_11_01760	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e pyrophosphokinase
Streptomyces sviceus	13980	SSEG_11017	7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)
Streptomyces venezuelae	13096	SVEN_3253	2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase
Streptosporangium roseum	3776	Sros_9170	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin ediphosphokinase
Synechococcus elongatus		Synpcc7942_2272	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Synechocystis sp.		slr1093	7,8-dihydro-6-hydroxymethylpterin- pyrophosphokinase
Thauera linaloolentis	102519	C666_12500	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase
Thermanaerovibrio acidaminovorans		Taci_0618	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Thermobispora bispora	14880	Tbis_3442	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Thermodesulfobium narugense	100082	Thena_1771	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Thermodesulfovibrio yellowstonii		THEYE_A1015	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Thermomicrobium roseum		trd_1324	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Thermomonospora curvata	15933	Tcur_4500	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Thermotoga lettingae	107922	Tlet_0265	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Thermotoga maritima	100826	TM_0041	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Thermotoga naphthophila	104846	Tnap_0672	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Thermotoga neapolitana	107923	CTN_0650	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Thermotoga petrophila	104847	Tpet_0882	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Thermotoga thermarum	107925	Theth_1341	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Thermus thermophilus	101084	TTHA1749	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (FolK)
Thermus thermophilus	101085	TT_C1387	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Tsukamurella paurometabola	16120	Tpau_0563	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin epyrophosphokinase
Turicella otitidis	106139	HMPREF9719_01342	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Vibrio alginolyticus	15630	N646_1600	2-amino-4-hydroxy-6-hydroxymethyldihydropteridin e pyrophosphokinase
Vibrio alginolyticus	15630	N646_2568	putative 2-amino-4-hydroxy-6-hydroxymethyldihydr opteridine pyrophosphokinase
Vibrio ichthyoenteri	15847	VII00023_12611	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Vibrio ichthyoenteri	15847	VII00023_21477	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Vibrio metschnikovii	103153	VIB_000307	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Vibrio orientalis	15638	VIOR3934_01065	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Vibrio orientalis	15638	VIOR3934_09855	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Vibrio tubiashii	15644	VITU9109_25805	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Vibrio tubiashii	15644	VITU9109_26015	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Vibrio vulnificus	15645	B736_10725	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Weeksella virosa	16016	Weevi_1465	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Xenococcus sp.		Xen7305DRAFT_00034500	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Xylanimonas cellulosilytica	107835	Xcel_2984	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase
Yersinia bercovieri	105717	yberc0001_11360	7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Yersinia rohdei	105715	yrohd0001_3670	7, 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase
Zimmermannella faecalis	15706	G328_13145	hypothetical protein
Zymomonas mobilis subsp. pomaceae	13757	Zymop_1468	2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase