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Rule : 3,4-dihydroxy-2-butanone 4-phosphate synthase (RIBB)

Rule Description

ID NRULE_0200
Rule name RIBB
Created 2013-04-09
Protein name
Protein name
Full
3,4-dihydroxy-2-butanone 4-phosphate synthase
Short
DHBP synthase
EC
EC 4.1.99.12
Gene name ribB
Rule Trigger PFAM; PF00926; hit=1
Cross Reference
Gene Ontology
GO
GO:0005829, C:cytosol, IDA:UniProtKB
GO:0005886, C:plasma membrane, IEA:UniProtKB-SubCell
GO:0008686, F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity, IDA:EcoCyc
GO:0000287, F:magnesium ion binding, IDA:EcoCyc
GO:0030145, F:manganese ion binding, IEA:HAMAP
GO:0006950, P:response to stress, IEA:UniProtKB-KW
GO:0009231, P:riboflavin biosynthetic process, IEA:HAMAP
Phylogenomic databases
eggNOG
COG0108, -
HOGENOM
HOG000115444, -
KO
K02858, -
ProtClustDB
PRK03353, -
Enzyme and pathway databases
BioCyc
MetaCyc:DIOHBUTANONEPSYN-MONOMER, -
BRENDA
4.1.99.12, 2166
UniPathway
UPA00275, UER00399
Family and domain databases
HAMAP
MF_00180, RibB, 1, -
InterPro
IPR017945, DHBP_synth_RibB-like_a/b_dom
IPR000422, DHBP_synthase_RibB
Pfam
PF00926, DHBP_synthase, 1
TIGRFAMs
TIGR00506, ribB, 1
Feature
P0A7J0 Escherichia coli (strain K12).
METAL38Magnesium or manganese 1 (By similarity).
METAL38Magnesium or manganese 2 (By similarity).
METAL153Magnesium or manganese 2 (By similarity).
BINDING42Substrate (By similarity).
BINDING174Substrate (By similarity).
SITE136Essential for catalytic activity.
SITE174Essential for catalytic activity.
General annotation
Function
Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Catalytic activity
D-ribulose 5-phosphate = formate + L-3,4- dihydroxybutan-2-one 4-phosphate
Cofactor
Binds 2 divalent metal cations per subunit. Magnesium or manganese
Pathway
Cofactor biosynthesis; riboflavin biosynthesis; 2- hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1
Subunit structure
Homodimer
Subcellular location
Cell membrane; Peripheral membrane protein (Potential)
Sequence similarities
Belongs to the DHBP synthase family
Reference
P0A7J0 Escherichia coli (strain K12).
1917833
The Escherichia coli htrP gene product is essential for bacterial growth at high temperatures: mapping, cloning, sequencing, and transcriptional regulation of htrP. (J Bacteriol. 1991)
1314093
Nucleotide sequence of a region duplicated in Escherichia coli toc mutants. (Biochim Biophys Acta. 1992)
1597419
Biosynthesis of riboflavin: cloning, sequencing, and expression of the gene coding for 3,4-dihydroxy-2-butanone 4-phosphate synthase of Escherichia coli. (J Bacteriol. 1992)
9278503
The complete genome sequence of Escherichia coli K-12. (Science. 1997)
16738553
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006)
11687623
The NMR structure of the 47-kDa dimeric enzyme 3,4-dihydroxy-2-butanone-4-phosphate synthase and ligand binding studies reveal the location of the active site. (Proc Natl Acad Sci U S A. 2001)
11342130
Crystal structure of 3,4-dihydroxy-2-butanone 4-phosphate synthase of riboflavin biosynthesis. (Structure. 2001)



Related Function

Function name
Riboflavin biosynthesis

CDS

Data Download
Scientific name NBRC No. CDS Product name
Acaricomes phytoseiuli107788C501_08370hypothetical protein
Acaryochloris marina102967AM1_0608riboflavin biosynthesis protein ribAB (3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II)
Acetobacter aceti14818AaceN1_010100007822bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acetobacter pasteurianus105190APA32_18560Bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acetobacter pasteurianus101655APT_1569bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acetobacter tropicalis101654ATPR_1353bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acholeplasma laidlawii14400ACL_1321bifunctional protein: 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II
Acidimicrobium ferrooxidans103882Afer_1683GTP cyclohydrolase II
Acidiphilium multivorum100883ACMV_236403,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Acidithiobacillus ferrooxidansLferr_04753,4-dihydroxy-2-butanone 4-phosphate synthase
Lferr_16633,4-dihydroxy-2-butanone 4-phosphate synthase
Acidobacterium capsulatum15755ACP_04203,4-dihydroxy-2-butanone 4-phosphate synthase/putative GTP cyclohydrolase II
Acinetobacter radioresistens102413ACRAD_14_007003,4-dihydroxy-2-butanone 4-phosphate synthase
ACRAD_18_005803,4-dihydroxy-2-butanone 4-phosphate synthase
Acinetobacter sp.100985ACT4_020_003403,4-dihydroxy-2-butanone 4-phosphate synthase
ACT4_021_019503,4-dihydroxy-2-butanone 4-phosphate synthase
Actinoalloteichus cyanogriseus14455G443_17_00310GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
Actinoalloteichus spitiensis102582ACTIDRAF_262203,4-dihydroxy-2-butanone 4-phosphate synthase
Actinomadura atramentaria14695G339_091203,4-dihydroxy-2-butanone 4-phosphate synthase
Actinoplanes missouriensis102363AMIS_61940"putative bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase"
Actinopolyspora iraqiensis103187ACTIR_363_00030GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
Actinosynnema mirum14064Amir_52183,4-dihydroxy-2-butanone 4-phosphate synthase
Aerococcus viridans12219HMPREF0061_14573,4-dihydroxy-2-butanone-4-phosphate synthase
Aeropyrum pernix100138APE_0986.13,4-dihydroxy-2-butanone 4-phosphate synthase
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_0938GTP cyclohydrolase II
Alloiococcus otitis15545HMPREF9698_00868GTP cyclohydrolase II
Alteromonas macleodii102226MASE_124153,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Amycolatopsis azurea14573C791_4907GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase
C791_69853,4-dihydroxy-2-butanone 4-phosphate synthase
Amycolatopsis mediterranei13415RAM_14095GTP cyclohydrolase II/3,4-dihydroxy 2-butanone 4-phosphate synthase
Anoxybacillus flavithermus15317Aflv_10173,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II
Aquifex aeolicusaq_350GTP cyclohydrolase II
Aquimarina agarilytica107695AagaZ_0201000079693,4-dihydroxy-2-butanone 4-phosphate synthase
Archaeoglobus profundus100127Arcpr_1140GTP cyclohydrolase II
Arcpr_12743,4-dihydroxy-2-butanone 4-phosphate synthase
Ardenticatena maritimaARMA_16043,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
Arthrobacter globiformis12137ARGLB_051_000903,4-dihydroxy-2-butanone 4-phosphate synthase
Austwickia chelonae105200AUCHE_05_05810GTP cyclohydrolase II
Azorhizobium caulinodans14845AZC_31023,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus amyloliquefaciens15535BAMF_2225fused GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus atrophaeus13721BATRMS_17_02760bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacillus cereus15305BC_4111GTP cyclohydrolase II
Bacillus licheniformis12200BL01889GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus licheniformis12195BLi02473bifunctional GTP cyclohydrolase II/ 3,4-dihydroxy-2-butanone 4-phosphate synthase RibA
Bacillus mojavensis15718GYU_39_00210bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacillus mycoides101228bmyco0001_37380GTP cyclohydrolase-2
Bacillus pseudomycoides101232bpmyx0001_359303,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus psychrosaccharolyticus101233WYK_005_000603,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus pumilus12092BAT_19583,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus subtilis3134BSU6633_14177bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacillus subtilis subsp. subtilis13719BSU23260fused GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone 4-phosphate synthase
Bacillus thuringiensis101235bthur0008_39040GTP cyclohydrolase-2
Bacillus vallismortis101236BvalD_010100002602bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Bacteroides vulgatus14291BVU_0143GTP cyclohydrolase II
BVU_03613,4-dihydroxy-2-butanone 4-phosphate synthase
Balneola vulgarisB155_RS01061153,4-dihydroxy-2-butanone-4-phosphate synthase
Bergeyella zoohelcum16014HMPREF9699_010483,4-dihydroxy-2-butanone-4-phosphate synthase
Bradyrhizobium diazoefficiens14792blr26153,4-dihydroxy-2-butanone-4-phoshate synthase/GTP cyclohydrolase II
Brevibacillus brevis100599BBR47_48120riboflavin biosynthesis protein RibA
Brevibacterium linens12170BlinB_010200002257bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Brevundimonas diminuta12697BDIM_116703,4-dihydroxy-2-butanone 4-phosphate synthase
Brevundimonas subvibrioides16000Bresu_18873,4-dihydroxy-2-butanone 4-phosphate synthase
Calditerrivibrio nitroreducens101217Calni_1658GTP cyclohydrolase II; 3,4-dihydroxy-2-butanone 4-phosphate synthase
Candidatus Nitrosopumilus sp.NSED_087453,4-dihydroxy-2-butanone 4-phosphate synthase
Candidatus Solibacter usitatusAcid_1908GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Catenulispora acidiphila102108Caci_3108GTP cyclohydrolase II
Cellulomonas fimi15513Celf_1963GTP cyclohydrolase II
Cellulomonas flavigena3775Cfla_1860GTP cyclohydrolase II
Cellulophaga lytica14961Celly_30373,4-dihydroxy-2-butanone 4-phosphate synthase
Cenarchaeum symbiosumCENSYa_17553,4-dihydroxy-2-butanone 4-phosphate synthase
Chitinispirillum alkaliphilumCHISP_10063,4-dihydroxy-2-butanone 4-phosphate synthase
Chitinivibrio alkaliphilusCALK_07013,4-dihydroxy-2-butanone 4-phosphate synthase
Chitinophaga pinensis15968Cpin_59343,4-dihydroxy-2-butanone 4-phosphate synthase
Chlamydia trachomatisCTL0100GTP cyclohydrolase II
Chloracidobacterium thermophilum BCabther_A1570GTP cyclohydrolase II
Chlorobaculum tepidum103806CT15913,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Chlorobium limicola103803Clim_01783,4-dihydroxy-2-butanone 4-phosphate synthase
Clim_19663,4-dihydroxy-2-butanone 4-phosphate synthase
Chromobacterium violaceum12614CV_2389riboflavin biosynthesis bifunctional protein : GTP cyclohydrolase ii and 3,4-dihydroxy-2-butanone-4-phosphate synthase
CV_42163,4-dihydroxy-2-butanone 4-phosphatesynthase protein
Chryseobacterium gleum15054HMPREF0204_117783,4-dihydroxy-2-butanone-4-phosphate synthase
HMPREF0204_119493,4-dihydroxy-2-butanone-4-phosphate synthase
Chrysiogenes arsenatisP304_RS01013803,4-dihydroxy-2-butanone 4-phosphate synthase
Chthoniobacter flavusCfE428DRAFT_46673,4-dihydroxy-2-butanone 4-phosphate synthase
Chthonomonas calidiroseaCCALI_00836GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Clostridium acetobutylicum13948CA_C0592Riboflavin biosynthes protein RIBA (GTPcyclohydrolase/3,4-dihydroxy-2-butanone 4-phosphate synthase)
Clostridium clariflavum101661Clocl_1126GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Clostridium kluyveri12016CKR_1902hypothetical protein
Clostridium thermocellum103400Cthe_01063,4-dihydroxy-2-butanone 4-phosphate synthase
Conexibacter woesei100937Cwoe_214334-dihydroxy-2-butanone 4-phosphate synthase
Cwoe_37063,4-dihydroxy-2-butanone 4-phosphate synthase
Cwoe_40213,4-dihydroxy-2-butanone 4-phosphate synthase
Congregibacter litoralis104960KT71_014003,4-dihydroxy-2-butanone 4-phosphate synthase
KT71_140793,4-dihydroxy-2-butanone 4-phosphate synthase
Coraliomargarita akajimensisCaka_09463,4-dihydroxy-2-butanone 4-phosphate synthase
Corynebacterium ammoniagenes12612HMPREF0281_004633,4-dihydroxy-2-butanone-4-phosphate synthase
Corynebacterium callunae15359H924_07545bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Corynebacterium efficiens100395CE17143,4-dihydroxy-2-butanone 4-phosphate synthase
Corynebacterium glutamicum12168Cgl1595GTP cyclohydrolase II
Corynebacterium glutamicum12153KIQ_10042bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Corynebacterium striatum15291HMPREF0308_06683,4-dihydroxy-2-butanone-4-phosphate synthase
Corynebacterium terpenotabidum14764A606_05850bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Cupriavidus metallidurans102507Rmet_2693bifunctional riboflavin biosynthesis protein RibBA: 3,4-dihydroxy-2-butanone-4-phosphate synthase and GTP cyclohydrolase II
Rmet_47583,4-dihydroxy-2-butanone 4-phosphate synthase
Cystobacter fuscus100088D187_0046053,4-dihydroxy-2-butanone 4-phosphate synthase
Cytophaga hutchinsonii15051CHU_0931GTP cyclohydrolase II
Deferribacter desulfuricans101012DEFDS_1098riboflavin biosynthesis bifunctional protein RibBA
Dehalococcoides mccartyiDehaBAV1_0999GTP cyclohydrolase II
Deinococcus proteolyticus101906Deipr_15953,4-dihydroxy-2-butanone 4-phosphate synthase
Desulfovibrio magneticus104933DMR_046103,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
DMR_352703,4-dihydroxy-2-butanone 4-phosphate synthase
Desulfovibrio vulgaris subsp. vulgaris104121DVU_11993,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
DVU_17753,4-dihydroxy-2-butanone 4-phosphate synthase
Edwardsiella tarda105688ET1_14_001603,4-dihydroxy-2-butanone 4-phosphate synthase
Endomicrobium proavitumEpro_05843,4-dihydroxy-2-butanone 4-phosphate synthase
Enterobacter aerogenes13534EAE_036153,4-dihydroxy-2-butanone 4-phosphate synthase
Enterobacter cloacae subsp. cloacae13535ECL_043763,4-dihydroxy-2-butanone 4-phosphate synthase
Enterobacter hormaechei105718HMPREF9086_38893,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Enterococcus hirae3181EHR_07320GTP cyclohydrolase II
Escherichia coli3972EcolC_06563,4-dihydroxy-2-butanone 4-phosphate synthase
Escherichia coli13500WFL_161703,4-dihydroxy-2-butanone 4-phosphate synthase
Escherichia coli12713Y75_30073,4 dihydroxy-2-butanone-4-phosphate synthase
Escherichia fergusonii102419EFER_29903,4-dihydroxy-2-butanone-4-phosphate synthase
Escherichia hermannii105704EH105704_19_001903,4-dihydroxy-2-butanone 4-phosphate synthase
Fibrobacter succinogenesFisuc_2736GTP cyclohydrolase II
Fimbriimonas ginsengisoliOP10G_23013,4-dihydroxy-2-butanone 4-phosphate synthase
Fischerella sp.PCC9339_RS01147503,4-dihydroxy-2-butanone 4-phosphate synthase
Flavobacterium johnsoniae14942Fjoh_21093,4-dihydroxy-2-butanone 4-phosphate synthase
Fjoh_40633,4-dihydroxy-2-butanone 4-phosphate synthase
Flexibacter litoralis15988Fleli_3848GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Fluviicola taffensis106335Fluta_3460GTP cyclohydrolase II
Frateuria aurantia3245Fraau_04523,4-dihydroxy-2-butanone 4-phosphate synthase
Fusobacterium nucleatum subsp. NucleatumFN1508GTP cyclohydrolase II
Gemmata obscuriglobusGEMOB_RS077453,4-dihydroxy-2-butanone 4-phosphate synthase
Gemmatimonas aurantiaca100505GAU_14733,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Geodermatophilus obscurus13315Gobs_3111GTP cyclohydrolase II
Gloeobacter violaceusglr0988riboflavin biosynthesis protein
Gluconacetobacter hansenii14816GXY_004193,4-dihydroxy-2-butanone 4-phosphate synthase
GXY_06875bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Gluconobacter frateurii101659GfraN1_0101000064263,4-Dihydroy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Gordonia aichiensis108223GOACH_01_003803,4-dihydroxy-2-butanone 4-phosphate synthase
GOACH_05_01980riboflavin biosynthesis protein RibBA
Gordonia alkanivorans16433GOALK_017_00310riboflavin biosynthesis protein RibBA
GOALK_033_01240riboflavin biosynthesis protein RibBA
GOALK_079_00020riboflavin biosynthesis protein RibBA
Gordonia amarae15530GOAMR_03_00650riboflavin biosynthesis protein RibBA
GOAMR_11_00140riboflavin biosynthesis bifunctional protein RibA
Gordonia amicalis100051GOAMI_01_01270GTP cyclohydrolase II
GOAMI_17_00660riboflavin biosynthesis protein ribBA
GOAMI_22_00610hypothetical protein
GOAMI_27_00660hypothetical protein
GOAMI_50_00170GTP cyclohydrolase II
Gordonia araii100433GOARA_064_00430GTP cyclohydrolase-2
Gordonia bronchialis16047Gbro_16933,4-dihydroxy-2-butanone 4-phosphate synthase
Gbro_2355GTP cyclohydrolase II
Gbro_412834-dihydroxy-2-butanone 4-phosphate synthase
Gordonia effusa100432GOEFS_049_00260riboflavin biosynthesis protein RibBA
Gordonia hirsuta16056GOHSU_18_00680riboflavin biosynthesis protein RibBA
Gordonia namibiensis108229GONAM_10_02400riboflavin biosynthesis protein RibBA
GONAM_12_00470riboflavin biosynthesis protein RibBA
GONAM_55_00030GTP cyclohydrolase II
Gordonia otitidis100426GOOTI_048_00130riboflavin biosynthesis protein RibBA
GOOTI_136_001303,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Gordonia polyisoprenivorans16320GOPIP_029_00160riboflavin biosynthesis protein RibBA
GOPIP_043_00580putative 3,4-dihydroxy-2-butanone 4-phosphate synthase
GOPIP_056_00850riboflavin biosynthesis protein RibBA
Gordonia rhizosphera16068GORHZ_026_00120riboflavin biosynthesis protein RibBA
GORHZ_085_00320GTP cyclohydrolase II
GORHZ_090_00140riboflavin biosynthesis protein RibBA
GORHZ_121_00230riboflavin biosynthesis protein RibBA
GORHZ_125_01200riboflavin biosynthesis protein RibBA
GORHZ_156_002103,4-dihydroxy-2-butanone 4-phosphate synthase
Gordonia rubripertincta101908GORBP_023_00020riboflavin biosynthesis protein RibBA
GORBP_039_01280riboflavin biosynthesis protein RibBA
Gordonia sihwensis108236GSI01S_03_00390riboflavin biosynthesis protein RibBA
Gordonia soli108243GS4_07_013403,4-dihydroxy-2-butanone 4-phosphate synthase
GS4_18_00660riboflavin biosynthesis protein RibBA
GS4_34_00490putative 3,4-dihydroxy-2-butanone 4-phosphate synthase
Gordonia sputi100414GOSPT_022_00650riboflavin biosynthesis protein RibBA
Gordonia terrae100016GOTRE_019_00080riboflavin biosynthesis protein RibBA
GOTRE_081_00470riboflavin biosynthesis protein RibBA
GOTRE_125_01110riboflavin biosynthesis protein RibBA
GOTRE_150_00310GTP cyclohydrolase II
GOTRE_181_003803,4-dihydroxy-2-butanone 4-phosphate synthase
Haloarcula vallismortis14741C437_177423,4-dihydroxy-2-butanone 4-phosphate synthase
Halobacillus halophilus102448HBHAL_4679bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase II protein
Halobacterium sp.VNG_2125GGTP cyclohydrolase II
Halomonas elongata15536HELO_3590bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Haloplasma contractileHLPCO_001293GTP cyclohydrolase II protein
Herpetosiphon aurantiacusHaur_13063,4-dihydroxy-2-butanone 4-phosphate synthase
Holophaga foetidaHOLFODRAFT_RS02075403,4-dihydroxy-2-butanone 4-phosphate synthase
HOLFODRAFT_RS02077903,4-dihydroxy-2-butanone 4-phosphate synthase
Hylemonella gracilis14920HGR_095033,4-dihydroxy-2-butanone 4-phosphate synthase
Hyphomonas neptunium14232HNE_2056riboflavin biosynthesis protein RibA
Ignavibacterium album101810IALB_21053,4-dihydroxy 2-butanone 4-phosphate synthase
Intrasporangium calvum12989Intca_1623GTP cyclohydrolase II; 3,4-dihydroxy-2-butanone 4-phosphate synthase
Jonesia denitrificans15587Jden_06823,4-dihydroxy-2-butanone 4-phosphate synthase
Kineococcus radiotolerans101839Krad_29783,4-dihydroxy-2-butanone 4-phosphate synthase
Kineosphaera limosa100340KILIM_040_00170GTP cyclohydrolase II
Kitasatospora setae14216KSE_11600putative 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Klebsiella pneumoniae14438KPR_4486
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_24723,4-dihydroxy-2-butanone-4-phosphate synthase
Kocuria rhizophila103217KRH_11700riboflavin synthase alpha chain/3,4-dihydroxy-2-butanone 4-phosphate synthase
Kordia algicida100336KAOT1_04560bifunctional protein: GTP cyclohydrolase II; 3,4 dihydroxy-2-butanone-4-phosphate synthase
Kribbella flavida14399Kfla_031434-dihydroxy-2-butanone 4-phosphate synthase
Kfla_51343,4-dihydroxy-2-butanone 4-phosphate synthase
Ktedonobacter racemiferKrac_21543,4-dihydroxy-2-butanone 4-phosphate synthase
Kyrpidia tusciae15312Btus_18243,4-dihydroxy-2-butanone 4-phosphate synthase
Kytococcus sedentarius15357Ksed_015703,4-dihydroxy-2-butanone 4-phosphate synthase
Labrenzia aggregata16684SIAM614_06963GTP cyclohydrolase II
Lactobacillus farciminis107150LfarK3_010100008236GTP cyclohydrolase II
Lactobacillus fermentum15885HMPREF0511_07763,4-dihydroxy-2-butanone-4-phosphate synthase
Lactobacillus fermentum3956LAF_0774GTP cyclohydrolase II
LAF_17723,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Lactobacillus plantarum subsp. plantarum15891HMPREF0531_10516GTP cyclohydrolase II
Lactobacillus reuteri15892LAR_0826GTP cyclohydrolase II
Leadbetterella byssophila106382Lbys_1704GTP cyclohydrolase II
Lentisphaera araneosaLNTAR_15832riboflavin synthase subunit alpha
LNTAR_181133,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
LNTAR_21910GTP cyclohydrolase II
Leptospira interrogansLA_1147bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Leuconostoc lactis107866EY7_758_000503,4-dihydroxy-2-butanone 4-phosphate synthase
Leuconostoc mesenteroides subsp. mesenteroides100496LEUM_0824GTP cyclohydrolase II
Leuconostoc pseudomesenteroides107767LpseK3_010100008361GTP cyclohydrolase II
LpseK3_010100011814GTP cyclohydrolase ii
Limnochorda pilosa110152LIP_33013,4-dihydroxy-2-butanone 4-phosphate synthase
Magnetospirillum gryphiswaldense15271MGR_2800bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2butanone-4-phosphate synthase
Magnetospirillum magnetotacticum15272Magn03005825COG0807: GTP cyclohydrolase II
Magn03009110COG0108: 3,4-dihydroxy-2-butanone 4-phosphate synthase
Marinomonas mediterranea103028Marme_04993,4-dihydroxy-2-butanone 4-phosphate synthase
Mariprofundus ferrooxydansSPV1_017073,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Marivirga tractuosa15989Ftrac_0930GTP cyclohydrolase II
Meiothermus ruber106122Mrub_1253GTP cyclohydrolase II
Meiothermus silvanus106475Mesil_3464hypothetical protein
Methanocaldococcus jannaschii100440MJ_0055GTP cyclohydrolase II (ribA)
Methanocella paludicola101707MCP_26703,4-dihydroxy-2-butanone 4-phosphate synthase
Methanococcus maripaludis101832MMP01833,4-dihydroxy-2-butanone 4-phosphate synthase
Methanococcus maripaludisMmarC5_14933,4-dihydroxy-2-butanone 4-phosphate synthase
Methanopyrus kandleriMK13973,4-dihydroxy-2-butanone 4-phosphate synthase
Methylacidiphilum infernorumMinf_24303,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II
Methylobacterium radiotolerans15690Mrad2831_27553,4-dihydroxy-2-butanone 4-phosphate synthase
Micrococcus luteus3333Mlut_10870GTP cyclohydrolase II /3,4-dihydroxy-2-butanone 4-phosphate synthase
Microlunatus phosphovorus101784MLP_153003,4-dihydroxy-2-butanone 4-phosphate synthase
Micromonospora aurantiaca16155Micau_23593,4-dihydroxy-2-butanone 4-phosphate synthase
Microscilla marina16560M23134_08222riboflavin biosynthesis protein ribAB
Mobilicoccus pelagius104925MOPEL_130_01580GTP cyclohydrolase II
Myroides odoratus14945Myrod_27203,4-dihydroxy-2-butanone 4-phosphate synthase
Myrod_35513,4-dihydroxy-2-butanone 4-phosphate synthase
Nakamurella multipartita105858Namu_41513,4-dihydroxy-2-butanone 4-phosphate synthase
Niastella koreensis106392Niako_0400GTP cyclohydrolase-2
Nitriliruptor alkaliphilusNitalDRAFT_24993,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
NitalDRAFT_34233,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
Nitrosomonas europaea14298NE2556ribAB; riboflavin biosynthesis bifunctional protein: GTP cyclohydrolase II and 3,4-dihydroxy-2-butanone-4-phosphate synthase
Nitrososphaera viennensisNVIE_0218803,4-dihydroxy-2-butanone 4-phosphate synthase
Nitrospina gracilisNITGR_910039Riboflavin biosynthesis protein RibBA
Nocardiopsis dassonvillei14626Ndas_08613,4-dihydroxy-2-butanone 4-phosphate synthase
Nostoc sp.all3536GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Oceanithermus profundus100410Ocepr_1717GTP cyclohydrolase II; 3,4-dihydroxy-2-butanone 4-phosphate synthase
Ochrobactrum anthropi15819Oant_05403,4-dihydroxy-2-butanone 4-phosphate synthase
Ochrobactrum intermedium15820OINT_10004803,4-dihydroxy-2-butanone 4-phosphate synthase
Oscillibacter valericigenes101213OBV_012503,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Paenibacillus alvei3343PAV_3c05350riboflavin biosynthesis protein RibBA
Paenibacillus peoriae15541PpeoK3_0101000053153,4-dihydroxy-2-butanone 4-phosphate synthase
Paenibacillus polymyxa15309PPT_167803,4-dihydroxy-2-butanone 4-phosphate synthase
Pedobacter heparinus12017Phep_35613,4-dihydroxy-2-butanone 4-phosphate synthase
Pedobacter saltans100064Pedsa_0362GTP cyclohydrolase II
Pelobacter carbinolicus103641Pcar_08843,4-dihydroxy-2-butanone-4-phosphate synthase
Pcar_14473,4-dihydroxy-2-butanone-4-phosphate synthase and GTP cyclohydrolase II
Pelobacter propionicus103807Ppro_03123,4-dihydroxy-2-butanone 4-phosphate synthase
Ppro_16523,4-dihydroxy-2-butanone 4-phosphate synthase
Phaeobacter gallaeciensis16654PGA1_c089203,4-dihydroxy-2-butanone 4-phosphate synthase RibB
Photobacterium damselae subsp. damselae corrig.15633VDA_0006133,4-dihydroxy-2-butanone 4-phosphate synthase
VDA_0026793,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Phycisphaera mikurensis102666PSMK_00420putative 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Picrophilus torridus100828PTO07123,4-dihydroxy-2-butanone 4-phosphate synthase
Planctomyces brasiliensis103401Plabr_4695GTP cyclohydrolase II
Prochlorococcus marinus subsp. marinusPro_09433,4-dihydroxy-2-butanone 4-phosphate synthase
Propionibacterium acidipropionici12425PACID_246503,4-dihydroxy-2-butanone-4-phosphate synthase
Propionibacterium avidum15671HMPREF9153_0359riboflavin biosynthesis protein ribBA
Proteus mirabilis105697HMPREF0693_25663,4-dihydroxy-2-butanone-4-phosphate synthase
Providencia alcalifaciens105687PROVALCAL_022533,4-dihydroxy-2-butanone-4-phosphate synthase
Pseudomonas putida100650PP_05163,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
PP_05303,4-dihydroxy-2-butanone 4-phosphate synthase
PP_38133,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Pseudomonas stutzeri14165PSTAB_0724bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein
Rahnella aquatilis105701Rahaq2_06473,4-dihydroxy-2-butanone 4-phosphate synthase
Renibacterium salmoninarum15589RSal33209_23463,4-dihydroxy-2-butanone 4-phosphate synthase
Rhizobium etli15573RHE_PD00121GTP cyclohydrolase II protein
Rhizobium sp.101917NGR_c05210riboflavin biosynthesis protein
Rhizobium tropici15247RTCIAT899_CH04470riboflavin biosynthesis protein ribBA
RTCIAT899_PA007453,4-dihydroxy-2-butanone 4-phosphate synthase
RTCIAT899_PC063853,4-dihydroxy-2-butanone 4-phosphate synthase
Rhodobacter capsulatus16581RCAP_rcc030753,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Rhodobacter sphaeroides12203RSP_0757GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Rhodococcus erythropolis100887RER_30220riboflavin biosynthesis bifunctional protein RibA
Rhodococcus opacus108011ROP_33020putative 3,4-dihydroxy-2-butanone 4-phosphate synthase
ROP_337303,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
ROP_46240putative 3,4-dihydroxy-2-butanone 4-phosphate synthase
ROP_466003,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
ROP_695103,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Roseobacter denitrificans15277RD1_18013,4-dihydroxy-2-butanone 4-phosphate synthase
Roseobacter litoralis15278RLO149_c029170riboflavin biosynthesis protein
Rothia dentocariosa12531HMPREF0733_11815riboflavin synthase, alpha subunit
Rothia mucilaginosa15673ROTMU0001_0385riboflavin synthase, alpha subunit
Rubrobacter xylanophilus100952Rxyl_0381GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Rxyl_1366GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharomonospora azurea14651SacazDRAFT_00051GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharomonospora cyanea14841SaccyDRAFT_1937GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharomonospora glauca14831SacglDRAFT_01790GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharomonospora viridis12207Svir_15730GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Svir_186703,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharopolyspora erythraea13426SACE_21233,4-dihydroxy-2-butanone 4-phosphate synthase
SACE_278634-dihydroxy-2-butanone 4-phosphate synthase
Saccharopolyspora spinosa15153SspiN1_010100016516GTP cyclohydrolase II
SspiN1_0101000264393,4-dihydroxy-2-butanone 4-phosphate synthase
SspiN1_0101000278593,4-dihydroxy-2-butanone 4-phosphate synthase
SspiN1_010100036704bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
SspiN1_0101000374493,4-dihydroxy-2-butanone 4-phosphate synthase
SspiN1_0101000376643,4-dihydroxy-2-butanone 4-phosphate synthase
Saccharothrix espanaensis15066BN6_62920Riboflavin biosynthesis protein ribBA
Salinibacter ruberSRU_00123,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
Salinispora arenicola105043Q5S_1271_00020bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Salinispora tropica105044Strop_1877GTP cyclohydrolase II
Sanguibacter keddieii16158Sked_18160GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Selenomonas ruminantium subsp. lactilytica103574SELR_09870putative riboflavin biosynthesis protein RibBA
Serratia odorifera102598HMPREF0758_19463,4-dihydroxy-2-butanone-4-phosphate synthase
Shimwellia blattae105725EB105725_20_001603,4-dihydroxy-2-butanone 4-phosphate synthase
Solitalea canadensis15130Solca_0222GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Sphingobacterium spiritivorum14948HMPREF0766_123873,4-dihydroxy-2-butanone-4-phosphate synthase
HMPREF0766_130953,4-dihydroxy-2-butanone-4-phosphate synthase
Sphingobium japonicum101211SJA_C1-02930GTP cyclohydrolase II
SJA_C2-03830GTP cyclohydrolase II
Sphingobium sp.103272SLG_348303,4-dihydroxy-2-butanone 4-phosphate synthase
SLG_368903,4-dihydroxy-2-butanone 4-phosphate synthase
Sphingomonas echinoides15742SechA1_0101000006203,4-dihydroxy-2-butanone 4-phosphate synthase
SechA1_0101000112533,4-dihydroxy-2-butanone 4-phosphate synthase
Sphingomonas wittichii105917Swit_10043,4-dihydroxy-2-butanone 4-phosphate synthase
Swit_24453,4-dihydroxy-2-butanone 4-phosphate synthase
Swit_37713,4-dihydroxy-2-butanone 4-phosphate synthase
Sporichthya polymorpha12702Spopo_31_16950GTP cyclohydrolase II
Stackebrandtia nassauensis102104Snas_25983,4-dihydroxy-2-butanone 4-phosphate synthase
Staphylococcus epidermidis12993SE_1439riboflavin biosynthesis protein
Staphylococcus saprophyticus subsp. saprophyticus102446SSP0997riboflavin biosynthesis protein
Starkeya novella14993Snov_44473,4-dihydroxy-2-butanone 4-phosphate synthase
Streptococcus equinus12553HMPREF0819_01413,4-dihydroxy-2-butanone-4-phosphate synthase
Streptomyces avermitilis14893SAV6904putative GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces cattleya14057SCAT_5373fused GTP cyclohydrolase II and 3, 4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces clavuligerus13307SCLAV_06783,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces ghanaensis15414SSFG_059253,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces mobaraensis13819H340_26731bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Streptomyces pristinaespiralis13074SSDG_036243,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces purpureus13925STRPU_03_008003,4-dihydroxy-2-butanone 4-phosphate synthase or GTP cyclohydrolase II
Streptomyces sviceus13980SSEG_098183,4-dihydroxy-2-butanone 4-phosphate synthase
Streptomyces venezuelae13096SVEN_10383,4-dihydroxy-2-butanone 4-phosphate synthase or GTP cyclohydrolase II
Streptosporangium roseum3776Sros_2835conserved hypothetical protein
Sulfolobus tokodaii100140STK_039203,4-dihydroxy-2-butanone 4-phosphate synthase
Synechococcus elongatusSynpcc7942_1432GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase
Synechocystis sp.sll1894GTP cyclohydrolase II
Thauera linaloolentis102519C666_13935bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein
Thermanaerovibrio acidaminovoransTaci_10083,4-dihydroxy-2-butanone 4-phosphate synthase
Thermobispora bispora14880Tbis_13743,4-dihydroxy-2-butanone 4-phosphate synthase
Thermodesulfobacterium communeHL41_002453,4-dihydroxy-2-butanone 4-phosphate synthase
Thermodesulfobium narugense100082Thena_1542GTP cyclohydrolase-2
Thermodesulfovibrio yellowstoniiTHEYE_A0208riboflavin biosynthesis protein RibA
Thermomicrobium roseumtrd_0504riboflavin biosynthesis protein ribA
Thermomonospora curvata15933Tcur_29953,4-dihydroxy-2-butanone 4-phosphate synthase
Thermoproteus neutrophilus100436Tneu_174134-dihydroxy-2-butanone 4-phosphate synthase
Thermotoga maritima100826TM_1826GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Thermotoga naphthophila104846Tnap_1001GTP cyclohydrolase II
Thermotoga neapolitana107923CTN_0758Riboflavin biosynthesis protein ribBA
Thermotoga petrophila104847Tpet_1111GTP cyclohydrolase II
Thermotoga thermarum107925Theth_1645GTP cyclohydrolase II
Thermus thermophilus101084TTHA1062GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase
Thermus thermophilus101085TT_C0697GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase
Tsukamurella paurometabola16120Tpau_2561GTP cyclohydrolase II
Turicella otitidis106139HMPREF9719_00717GTP cyclohydrolase II
Vibrio alginolyticus15630N646_28343,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
N646_38593,4-dihydroxy-2-butanone 4-phosphate synthase
Vibrio ichthyoenteri15847VII00023_026093,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
VII00023_223013,4-dihydroxy-2-butanone 4-phosphate synthase
Vibrio metschnikovii103153VIB_0006573,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
VIB_0025633,4-dihydroxy-2-butanone 4-phosphate synthase
Vibrio orientalis15638VIOR3934_141223,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
VIOR3934_155263,4-dihydroxy-2-butanone 4-phosphate synthase
VIOR3934_191303,4-dihydroxy-2-butanone 4-phosphate synthase
Vibrio tubiashii15644VITU9109_052413,4-dihydroxy-2-butanone 4-phosphate synthase
VITU9109_06220GTP cyclohydrolase II
Vibrio vulnificus15645B736_090803,4-dihydroxy-2-butanone 4-phosphate synthase
B736_130003,4-dihydroxy-2-butanone 4-phosphate synthase
Weeksella virosa16016Weevi_07613,4-dihydroxy-2-butanone 4-phosphate synthase
Xenococcus sp.Xen7305DRAFT_00032940GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
Xylanimonas cellulosilytica107835Xcel_1728GTP cyclohydrolase II
Yersinia bercovieri105717yberc0001_348003,4-dihydroxy-2-butanone 4-phosphate synthase
Yersinia rohdei105715yrohd0001_168503,4-dihydroxy-2-butanone 4-phosphate synthase
Zimmermannella faecalis15706G328_10485hypothetical protein
Zymomonas mobilis subsp. pomaceae13757Zymop_07443,4-dihydroxy-2-butanone 4-phosphate synthase