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遺伝子 : Bifunctional protein FolC (FOLC)

遺伝子情報

ID NRULE_0160
遺伝子ID FOLC
作成日 2013/03/12
タンパク質名
Protein name
Full
Bifunctional protein FolC
遺伝子名 folC
遺伝子条件 TIGRFAMs; TIGR01499; hit=1
参照
Gene Ontology
GO
GO:0005737, C:cytoplasm, IDA:EcoliWiki
GO:0005524, F:ATP binding, IEA:UniProtKB-KW
GO:0008841, F:dihydrofolate synthase activity, IDA:EcoliWiki
GO:0004326, F:tetrahydrofolylpolyglutamate synthase activity, IDA:EcoliWiki
GO:0046656, P:folic acid biosynthetic process, IEA:UniProtKB-KW
GO:0006730, P:one-carbon metabolic process, IEA:UniProtKB-KW
GO:0046654, P:tetrahydrofolate biosynthetic process, IEA:UniProtKB-UniPathway
Phylogenomic databases
eggNOG
COG0285, -
HOGENOM
HOG000019982, -
KO
K11754, -
ProtClustDB
PRK10846, -
Enzyme and pathway databases
BioCyc
MetaCyc:FOLC-MONOMER, -
UniPathway
UPA00077, UER00157
Family and domain databases
InterPro
IPR001645, Folylpolyglutamate_synth
IPR018109, Folylpolyglutamate_synth_CS
IPR004101, Mur_ligase_C
IPR013221, Mur_ligase_cen
Pfam
PF02875, Mur_ligase_C, 1
PF08245, Mur_ligase_M, 1
PIRSF
PIRSF001563, Folylpolyglu_synth, 1
TIGRFAMs
TIGR01499, folC, 1
PROSITE
PS01011, FOLYLPOLYGLU_SYNT_1, 1
PS01012, FOLYLPOLYGLU_SYNT_2, 1
配列の特徴 該当データなし
注釈
Function
Conversion of folates to polyglutamate derivatives
Catalytic activity
ATP + tetrahydropteroyl-(gamma-Glu)(n) + L- glutamate = ADP + phosphate + tetrahydropteroyl-(gamma-Glu)(n+1)
ATP + 7,8-dihydropteroate + L-glutamate = ADP + phosphate + 7,8-dihydropteroylglutamate
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine diphosphate and 4-aminobenzoate: step 2/2
Subunit structure
Monomer
Sequence similarities
Belongs to the folylpolyglutamate synthase family
参考文献
P08192 Escherichia coli (strain K12).
3040739
Primary structure of the Escherichia coli folC gene and its folylpolyglutamate synthetase-dihydrofolate synthetase product and regulation of expression by an upstream gene. (J Biol Chem. 1987)
3040734
The hisT-purF region of the Escherichia coli K-12 chromosome. Identification of additional genes of the hisT and purF operons. (J Biol Chem. 1987)
9205837
Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features. (DNA Res. 1997)
9278503
The complete genome sequence of Escherichia coli K-12. (Science. 1997)
16738553
Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. (Mol Syst Biol. 2006)



関与する機能

機能名
Folate biosynthesis

該当CDS

データダウンロード
学名 NBRC番号 CDS タンパク質名
Acaricomes phytoseiuli107788C501_11755dihydrofolate synthase
Acaryochloris marina102967AM1_1737FolC bifunctional protein (Includes: folylpolyglutamate synthetase and dihydrofolate synthetase)
Acetobacter aceti14818AaceN1_010100001373folylpoly-gamma-glutamate synthetase
Acetobacter pasteurianus105190APA32_26070Bifunctional protein FolC
Acetobacter pasteurianus101655APT_0695bifunctional protein FolC
Acetobacter tropicalis101654ATPR_1145bifunctional protein FolC
Acholeplasma laidlawii14400ACL_0542folylpolyglutamate synthase
Acidimicrobium ferrooxidans103882Afer_0764FolC bifunctional protein
Acidiphilium multivorum100883ACMV_10690folylpolyglutamate synthase
Acidithiobacillus ferrooxidansLferr_1724FolC bifunctional protein
Acidobacterium capsulatum15755ACP_2169tetrahydrofolate synthase
Acinetobacter radioresistens102413ACRAD_34_00080folylpolyglutamate synthase/dihydrofolate synthase
Acinetobacter sp.100985ACT4_031_00380folylpolyglutamate synthase
Actinoalloteichus cyanogriseus14455G443_13_00540dihydrofolate synthase
Actinoalloteichus spitiensis102582ACTIDRAF_19355hypothetical protein
Actinomadura atramentaria14695G339_06950hypothetical protein
Actinoplanes missouriensis102363AMIS_11300putative folylpolyglutamate synthase
Actinopolyspora iraqiensis103187ACTIR_280_00040dihydrofolate synthase
Actinosynnema mirum14064Amir_1166FolC bifunctional protein
Aerococcus viridans12219HMPREF0061_0388bifunctional protein FolC
HMPREF0061_0615bifunctional protein FolC
Alicyclobacillus acidocaldarius subsp. acidocaldarius15652Aaci_1830FolC bifunctional protein
Aaci_2223FolC bifunctional protein
Alloiococcus otitis15545HMPREF9698_00692FolC protein
HMPREF9698_01529FolC protein
Alteromonas macleodii102226MASE_11665bifunctional folylpolyglutamate synthase/dihydrofolate synthase
Amycolatopsis azurea14573C791_3731Dihydrofolate synthase
Amycolatopsis mediterranei13415RAM_34460dihydrofolate synthase
Anaerolinea thermophila100420ANT_15320folylpolyglutamate synthetase
Anoxybacillus flavithermus15317Aflv_0615Folylpolyglutamate synthase
Aquifex aeolicusaq_2045folylpolyglutamate synthetase
Aquimarina agarilytica107695AagaZ_020100000657bifunctional folylpolyglutamate synthase/dihydrofolate synthase
Arcanobacterium haemolyticum15585Arch_0554FolC bifunctional protein
Ardenticatena maritimaARMA_1765dihydrofolate synthase / folylpolyglutamate synthase
Arthrobacter globiformis12137ARGLB_074_00540folylpolyglutamate synthase
Atopobium rimae15546ATORI0001_0349bifunctional protein FolC
Austwickia chelonae105200AUCHE_05_02790folylpolyglutamate synthase
Azorhizobium caulinodans14845AZC_1025folylpolyglutamate synthetase
Bacillus amyloliquefaciens15535BAMF_2614folyl-polyglutamate synthase
Bacillus atrophaeus13721BATRMS_07_00460folyl-polyglutamate synthase
Bacillus cereus15305BC_4464Folylpolyglutamate synthase
Bacillus licheniformis12200BL00632folyl-polyglutamate synthetase
Bacillus licheniformis12195BLi02937bifunctional tetrahydrofolylpolyglutamate synthase/dihydrofolate synthase FolC
Bacillus mojavensis15718GYU_44_01660folyl-polyglutamate synthase
Bacillus mycoides101228bmyco0001_40810Folyl-polyglutamate synthetase
Bacillus pseudomycoides101232bpmyx0001_39320Folyl-polyglutamate synthetase
Bacillus psychrosaccharolyticus101233WYK_248_00430Folyl-polyglutamate synthetase
Bacillus pumilus12092BAT_1489folylpolyglutamate synthase
Bacillus subtilis3134BSU6633_11093folyl-polyglutamate synthase
Bacillus subtilis subsp. subtilis13719BSU28080folyl-polyglutamate synthase
Bacillus thuringiensis101235bthur0008_42600Folyl-polyglutamate synthetase
Bacillus vallismortis101236BvalD_010100014128folyl-polyglutamate synthase
Bacteroides vulgatus14291BVU_2328putative folylpolyglutamate synthase
Balneola vulgarisB155_RS0100145folylpolyglutamate synthase
Bergeyella zoohelcum16014HMPREF9699_00636FolC protein
Beutenbergia cavernae16432Bcav_2567FolC bifunctional protein
Bradyrhizobium diazoefficiens14792blr0748folylpolyglutamate synthase
Brevibacillus brevis100599BBR47_18250folylpolyglutamate synthase
Brevibacterium linens12170BlinB_010200013381dihydrofolate synthase
Brevundimonas diminuta12697BDIM_27300FolC family protein
Brevundimonas subvibrioides16000Bresu_3218FolC bifunctional protein
Caldanaerobacter subterraneus subsp. tengcongensis100824TTE0783Folylpolyglutamate synthase
Caldilinea aerophila104270CLDAP_15620folylpolyglutamate synthase
Caldisericum exile104410CSE_12110folylpolyglutamate synthetase
Calditerrivibrio nitroreducens101217Calni_0051FolC bifunctional protein
Candidatus Solibacter usitatusAcid_5660FolC bifunctional protein
Catenulispora acidiphila102108Caci_7289FolC bifunctional protein
Caulobacter segnis15250Cseg_0144FolC bifunctional protein
Cellulomonas fimi15513Celf_1484FolC bifunctional protein
Cellulomonas flavigena3775Cfla_1456FolC bifunctional protein
Cellulophaga lytica14961Celly_2042FolC bifunctional protein
Chitinispirillum alkaliphilumCHISP_3368Dihydrofolate synthase
Chitinivibrio alkaliphilusCALK_0186folylpolyglutamate synthase
Chitinophaga pinensis15968Cpin_3070FolC bifunctional protein
Chloracidobacterium thermophilum BCabther_A0524folylpolyglutamate synthase/dihydrofolate synthase
Chlorobaculum tepidum103806CT0263folylpolyglutamate synthase
Chlorobium limicola103803Clim_0322FolC bifunctional protein
Chromobacterium violaceum12614CV_2518folylpolyglutamate synthase/dihydrofolate synthase
Chryseobacterium gleum15054HMPREF0204_10303bifunctional protein FolC
Chrysiogenes arsenatisP304_RS14785hypothetical protein
Chthoniobacter flavusCfE428DRAFT_2028FolC bifunctional protein
Chthonomonas calidiroseaCCALI_02639folylpolyglutamate synthase/dihydrofolate synthase
Clostridium acetobutylicum13948CA_C2398Folylpolyglutamate synthase
Clostridium clariflavum101661Clocl_2605folylpolyglutamate synthase/dihydrofolate synthase
Clostridium kluyveri12016CKR_2851hypothetical protein
Clostridium thermocellum103400Cthe_1384FolC bifunctional protein
Conexibacter woesei100937Cwoe_2653FolC bifunctional protein
Congregibacter litoralis104960KT71_14794folylpolyglutamate synthase/dihydrofolate synthase
Coprobacillus sp.HMPREF1021_01725FolC protein
HMPREF1021_03060FolC protein
Coraliomargarita akajimensisCaka_1970FolC bifunctional protein
Corynebacterium ammoniagenes12612HMPREF0281_01273bifunctional protein FolC
Corynebacterium callunae15359H924_10000folylpolyglutamate synthase
Corynebacterium efficiens100395CE2281putative folylpolyglutamate synthase
Corynebacterium glutamicum12168Cgl2375Folylpolyglutamate synthase
Corynebacterium glutamicum12153KIQ_00625folylpolyglutamate synthase
Corynebacterium matruchotii15360HMPREF0299_7045bifunctional protein FolC
Corynebacterium striatum15291HMPREF0308_0306bifunctional protein FolC
Corynebacterium terpenotabidum14764A606_03560dihydrofolate synthase / folylpolyglutamate synthase
Cupriavidus metallidurans102507Rmet_2463bifunctional folylpolyglutamate synthase and dihydrofolate synthase
Cystobacter fuscus100088D187_005833Dihydrofolate synthase
Cytophaga hutchinsonii15051CHU_1542tetrahydrofolylpolyglutamate synthase (folylpolyglutamate synthetase)
Deferribacter desulfuricans101012DEFDS_0578folylpolyglutamate synthase
Dehalococcoides mccartyiDehaBAV1_0015FolC bifunctional protein
Deinococcus proteolyticus101906Deipr_0091FolC bifunctional protein
Deipr_1878FolC bifunctional protein
Desulfovibrio magneticus104933DMR_30530folylpolyglutamate synthase
Desulfovibrio vulgaris subsp. vulgaris104121DVU_2882folylpolyglutamate synthase
Dictyoglomus turgidumDtur_0758FolC bifunctional protein
Edwardsiella tarda105688ET1_09_00120folylpolyglutamate synthase/dihydrofolate synthase
Elusimicrobium minutumEmin_1092Putative folylpoly-gamma-glutamate synthetase
Endomicrobium proavitumEpro_0428Folylpolyglutamate synthetase
Enterobacter aerogenes13534EAE_24575bifunctional folylpolyglutamate synthase/ dihydrofolate synthase
Enterobacter cloacae subsp. cloacae13535ECL_03664bifunctional folylpolyglutamate synthase/dihydrofolate synthase
Enterobacter hormaechei105718HMPREF9086_3231dihydrofolate:folylpolyglutamate synthetase
Enterococcus gilvus100696I592_00706folylpolyglutamate synthase
Enterococcus haemoperoxidus100709I583_02261FolC family protein
Enterococcus hirae3181EHR_07765FolC family protein
Enterococcus italicus107825HMPREF9088_1820bifunctional protein FolC
Enterococcus moraviensis100710I586_01265FolC family protein
Enterococcus pallens100697I588_03441folylpolyglutamate synthase
Enterococcus phoeniculicola100711I589_02874folylpolyglutamate synthase
Escherichia coli3972EcolC_1337FolC bifunctional protein
Escherichia coli13500WFL_12260bifunctional folylpolyglutamate synthase/ dihydrofolate synthase
Escherichia coli12713Y75_2321bifunctional folylpolyglutamate synthase and dihydrofolate synthase
Escherichia fergusonii102419EFER_0848bifunctional folylpolyglutamate synthase and dihydrofolate synthase
Escherichia hermannii105704EH105704_01_07590folylpolyglutamate synthase/dihydrofolate synthase
Fibrobacter succinogenesFisuc_0203FolC bifunctional protein
Fimbriimonas ginsengisoliOP10G_4020FolC bifunctional protein
Finegoldia magnaFMG_1087folylpolyglutamate synthase
Fischerella sp.PCC9339_RS0112500folylpolyglutamate synthase
Flavobacterium johnsoniae14942Fjoh_0461FolC bifunctional protein
Flexibacter litoralis15988Fleli_3290folylpolyglutamate synthase/dihydrofolate synthase
Fluviicola taffensis106335Fluta_2537FolC bifunctional protein
Frateuria aurantia3245Fraau_2172folylpolyglutamate synthase/dihydrofolate synthase
Fructobacillus fructosus3516EWM_31_00030folylpolyglutamate synthase
Fusobacterium nucleatum subsp. NucleatumFN1014Folylpolyglutamate synthase
Gemmata obscuriglobusGEMOB_RS43225FolC bifunctional protein
Gemmatimonas aurantiaca100505GAU_1755folylpolyglutamate synthase
Geodermatophilus obscurus13315Gobs_1582FolC bifunctional protein
Gobs_2872FolC bifunctional protein
Gloeobacter violaceusglr1074folylpolyglutamate synthase
Gluconacetobacter hansenii14816GXY_01108putative folylpoly-gamma-glutamate synthetase
Gluconobacter frateurii101659GfraN1_010100008851bifunctional folylpolyglutamate synthase/ dihydrofolate synthase
Gordonia aichiensis108223GOACH_17_00260folylpolyglutamate synthase
Gordonia alkanivorans16433GOALK_040_00520folylpolyglutamate synthase
Gordonia amarae15530GOAMR_67_00140folylpolyglutamate synthase
Gordonia amicalis100051GOAMI_27_00840folylpolyglutamate synthase
Gordonia araii100433GOARA_063_01960folylpolyglutamate synthase
Gordonia bronchialis16047Gbro_2054FolC bifunctional protein
Gordonia effusa100432GOEFS_046_00540folylpolyglutamate synthase
Gordonia hirsuta16056GOHSU_22_00050folylpolyglutamate synthase
Gordonia namibiensis108229GONAM_16_00800folylpolyglutamate synthase
Gordonia otitidis100426GOOTI_217_00290folylpolyglutamate synthase
Gordonia polyisoprenivorans16320GOPIP_070_00590folylpolyglutamate synthase
Gordonia rhizosphera16068GORHZ_200_00230folylpolyglutamate synthase
GORHZ_223_00100folylpolyglutamate synthase
Gordonia rubripertincta101908GORBP_068_01310folylpolyglutamate synthase
Gordonia sihwensis108236GSI01S_15_01120folylpolyglutamate synthase
Gordonia soli108243GS4_20_01050folylpolyglutamate synthase
Gordonia sputi100414GOSPT_051_00950folylpolyglutamate synthase
Gordonia terrae100016GOTRE_026_01090folylpolyglutamate synthase
Haloarcula vallismortis14741C437_07682dihydropteroate synthase
C437_09508dihydropteroate synthase
Halobacillus halophilus102448HBHAL_3672folylpolyglutamate synthase
Halobacterium sp.VNG_0412Gdihydropteroate synthase
Halomonas elongata15536HELO_2241FolC bifunctional protein
Haloplasma contractileHLPCO_001127Folylpolyglutamate synthase protein
Herpetosiphon aurantiacusHaur_0603FolC bifunctional protein
Holophaga foetidaHOLFODRAFT_RS21270hypothetical protein
Hylemonella gracilis14920HGR_07936FolC bifunctional protein
Hyphomonas neptunium14232HNE_3472putative folylpolyglutamate synthase
Ignavibacterium album101810IALB_1616Folylpolyglutamate synthase
Intrasporangium calvum12989Intca_2212FolC bifunctional protein
Jonesia denitrificans15587Jden_0971FolC bifunctional protein
Kineococcus radiotolerans101839Krad_3497FolC bifunctional protein
Kineosphaera limosa100340KILIM_050_00330folylpolyglutamate synthase
Kitasatospora setae14216KSE_04510putative folylpolyglutamate synthase
KSE_26190putative folylpolyglutamate synthase
Klebsiella pneumoniae14438KPR_2001
Klebsiella pneumoniae subsp. rhinoscleromatis105682HMPREF0484_3507bifunctional protein FolC
Kocuria rhizophila103217KRH_11240folylpolyglutamate synthase
Kordia algicida100336KAOT1_20987putative folylpolyglutamate synthase
Kribbella flavida14399Kfla_2291FolC bifunctional protein
Ktedonobacter racemiferKrac_7665FolC bifunctional protein
Kyrpidia tusciae15312Btus_0662FolC bifunctional protein
Btus_3117FolC bifunctional protein
Kytococcus sedentarius15357Ksed_09160folylpolyglutamate synthase/dihydrofolate synthase
Labrenzia aggregata16684SIAM614_27547probable folc bifunctional protein includes: folylpolyglutamate synthase and dihydrofolate synthase
Lactobacillus acidipiscis102164LaciK1_010100001372folylpolyglutamate synthase
Lactobacillus animalis15882LaniK3_010100003538folylpolyglutamate synthase
Lactobacillus casei15883LCABL_14820Folylpolyglutamate synthase (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolate synthase) (Tetrahydrofolylpolyglutamate synthase)
Lactobacillus delbrueckii subsp. bulgaricus13953Ldb0248Folylpolyglutamate synthase
Ldb0728Folylpolyglutamate synthase
Lactobacillus farciminis107150LfarK3_010100008776folylpolyglutamate synthase
Lactobacillus fermentum15885HMPREF0511_0632bifunctional protein FolC
HMPREF0511_1712bifunctional protein FolC
Lactobacillus fermentum3956LAF_0498folylpolyglutamate synthase
LAF_1338folylpolyglutamate synthase
Lactobacillus fructivorans13954LACFR_07_00120folylpolyglutamate synthase
Lactobacillus helveticus15019HMPREF0518_0256bifunctional protein FolC
HMPREF0518_1377bifunctional protein FolC
Lactobacillus hilgardii15886HMPREF0519_2022bifunctional protein FolC
HMPREF0519_2228hypothetical protein
Lactobacillus plantarum subsp. plantarum15891HMPREF0531_12977bifunctional protein FolC
HMPREF0531_13072bifunctional protein FolC
Lactobacillus reuteri15892LAR_0496folylpolyglutamate synthase
LAR_1210folylpolyglutamate synthase
Leadbetterella byssophila106382Lbys_0928FolC bifunctional protein
Lentisphaera araneosaLNTAR_16017Folylpolyglutamate synthase
Leptospira interrogansLA_0637dihydrofolate synthase
Leuconostoc lactis107866EY7_1058_00010Folylpolyglutamate synthase
EY7_330_00010Folylpolyglutamate synthase
EY7_705_00010Folylpolyglutamate synthase
EY7_711_00010Folylpolyglutamate synthase
Leuconostoc mesenteroides subsp. cremoris107766HMPREF0555_1202bifunctional protein FolC
HMPREF0555_1486bifunctional protein FolC
Leuconostoc mesenteroides subsp. mesenteroides100496LEUM_0455Folylpolyglutamate synthase
LEUM_0733Folylpolyglutamate synthase
Leuconostoc pseudomesenteroides107767LpseK3_010100003066folylpolyglutamate synthase
LpseK3_010100019196folylpolyglutamate synthase
Limnochorda pilosa110152LIP_2801folylpolyglutamate synthase
Magnetospirillum gryphiswaldense15271MGR_3664Folylpolyglutamate synthase
Magnetospirillum magnetotacticum15272Magn03005310COG0285: Folylpolyglutamate synthase
Magn03010577COG0285: Folylpolyglutamate synthase
Marinomonas mediterranea103028Marme_2076FolC bifunctional protein
Mariprofundus ferrooxydansSPV1_13337Folylpolyglutamate synthetase
Marivirga tractuosa15989Ftrac_0330FolC bifunctional protein
Meiothermus ruber106122Mrub_2632FolC bifunctional protein
Meiothermus silvanus106475Mesil_0351FolC bifunctional protein
Mesil_2502FolC bifunctional protein
Mesoplasma florum100688Mfl060putative folyl-polyglutamate synthetase
Methylacidiphilum infernorumMinf_0385Folylpolyglutamate synthase
Methylobacterium radiotolerans15690Mrad2831_3380FolC bifunctional protein
Micrococcus luteus3333Mlut_10060folylpolyglutamate synthase/dihydrofolate synthase
Microlunatus phosphovorus101784MLP_36450folylpolyglutamate synthase
Micromonospora aurantiaca16155Micau_4903FolC bifunctional protein
Microscilla marina16560M23134_02089folylpolyglutamate synthase
Mobilicoccus pelagius104925MOPEL_132_00810folylpolyglutamate synthase
Myroides odoratus14945Myrod_2770FolC bifunctional protein
Nakamurella multipartita105858Namu_1496FolC bifunctional protein
Niastella koreensis106392Niako_2087FolC bifunctional protein
Nitriliruptor alkaliphilusNitalDRAFT_4985dihydrofolate synthase / folylpolyglutamate synthase
Nitrosomonas europaea14298NE0696Cytoplasmic peptidoglycan synthetases, C-terminal
Nitrospina gracilisNITGR_600012Folylpolyglutamate synthase
Nocardiopsis dassonvillei14626Ndas_3391FolC bifunctional protein
Nostoc sp.alr1026folylpolyglutamate synthase
Oceanithermus profundus100410Ocepr_0875FolC bifunctional protein
Ocepr_1874FolC bifunctional protein
Ochrobactrum anthropi15819Oant_0814FolC bifunctional protein
Ochrobactrum intermedium15820OINT_1002460Folylpolyglutamate synthetase
Oscillibacter valericigenes101213OBV_12290folylpolyglutamate synthase
Paenibacillus alvei3343PAV_4c01240folylpolyglutamate synthase FolC
Paenibacillus peoriae15541PpeoK3_010100016810Folylpolyglutamate synthase (Folylpoly-gamma-glutamate synthetase)
Paenibacillus polymyxa15309PPT_21180folylpolyglutamate synthase
Pedobacter heparinus12017Phep_1166FolC bifunctional protein
Pedobacter saltans100064Pedsa_1924FolC bifunctional protein
Pelobacter carbinolicus103641Pcar_0738folylpolyglutamate synthetase
Pelobacter propionicus103807Ppro_1160FolC bifunctional protein
Phaeobacter gallaeciensis16654PGA1_c31680putative bifunctional enzyme FolC
Photobacterium damselae subsp. damselae corrig.15633VDA_001538dihydrofolate synthase/folylpolyglutamate synthase
Phycisphaera mikurensis102666PSMK_11030folylpolyglutamate synthetase
Picrophilus torridus100828PTO1256folylpolyglutamate synthase/dihydrofolate synthase
Planctomyces brasiliensis103401Plabr_2429FolC bifunctional protein
Prochlorococcus marinus subsp. marinusPro_1376Folylpolyglutamate synthase
Propionibacterium acidipropionici12425PACID_13240Bifunctional protein FolC
Propionibacterium avidum15671HMPREF9153_2104tetrahydrofolate synthase
Proteus mirabilis105697HMPREF0693_1429bifunctional protein FolC
Providencia alcalifaciens105687PROVALCAL_03339bifunctional protein FolC
Pseudomonas putida100650PP_1997folylpolyglutamate synthetase
Pseudomonas stutzeri14165PSTAB_1679folylpolyglutamate synthetase
Rahnella aquatilis105701Rahaq2_1305folylpolyglutamate synthase/dihydrofolate synthase
Renibacterium salmoninarum15589RSal33209_3257folylpolyglutamate synthase
Rhizobium etli15573RHE_CH00024bifunctional folylpolyglutamate synthase/dihydrofolate syntase
Rhizobium sp.101917NGR_c33810FolC bifunctional protein
Rhizobium tropici15247RTCIAT899_CH00140zinc-binding oxidoreductase protein
RTCIAT899_CH10395folylpolyglutamate synthase
Rhodobacter capsulatus16581RCAP_rcc00235folylpolyglutamate synthase/dihydrofolate synthase
Rhodobacter sphaeroides12203RSP_0930Folylpolyglutamate synthetase
Rhodococcus erythropolis100887RER_37990folylpolyglutamate synthase
Rhodococcus opacus108011ROP_10390folylpolyglutamate synthase
Roseobacter denitrificans15277RD1_0327folC bifunctional protein
Roseobacter litoralis15278RLO149_c042580putative bifunctional enzyme FolC
Rothia dentocariosa12531HMPREF0733_12077bifunctional protein FolC
Rothia mucilaginosa15673ROTMU0001_0951bifunctional protein FolC
Rubrobacter xylanophilus100952Rxyl_1534FolC bifunctional protein
Saccharomonospora azurea14651SacazDRAFT_04080folylpolyglutamate synthase/dihydrofolate synthase
Saccharomonospora cyanea14841SaccyDRAFT_1458folylpolyglutamate synthase/dihydrofolate synthase
SaccyDRAFT_2694folylpolyglutamate synthase/dihydrofolate synthase
Saccharomonospora glauca14831SacglDRAFT_01359folylpolyglutamate synthase/dihydrofolate synthase
Saccharomonospora viridis12207Svir_12370folylpolyglutamate synthase/dihydrofolate synthase
Saccharopolyspora erythraea13426SACE_1387folylpolyglutamate synthase
Saccharopolyspora spinosa15153SspiN1_010100015010dihydrofolate synthase
Saccharothrix espanaensis15066BN6_13950FolC bifunctional protein
Salinibacter ruberSRU_2420dihydrofolate synthetase
Salinispora arenicola105043Q5S_2514_00010folylpolyglutamate synthase
Salinispora tropica105044Strop_3492FolC bifunctional protein
Sanguibacter keddieii16158Sked_23910folylpolyglutamate synthase/dihydrofolate synthase
Selenomonas ruminantium subsp. lactilytica103574SELR_10370putative folyl-polyglutamate synthetase
Serratia odorifera102598HMPREF0758_2759bifunctional protein FolC
Shimwellia blattae105725EB105725_04_00300folylpolyglutamate synthase/dihydrofolate synthase
Solitalea canadensis15130Solca_0669folylpolyglutamate synthase/dihydrofolate synthase
Sphingobacterium spiritivorum14948HMPREF0766_11044bifunctional protein FolC
Sphingobium japonicum101211SJA_C1-21390folylpolyglutamate synthase
Sphingobium sp.103272SLG_13670folylpolyglutamate synthetase
Sphingomonas echinoides15742SechA1_010100017759folylpolyglutamate synthase
Sphingomonas wittichii105917Swit_2729FolC bifunctional protein
Sporichthya polymorpha12702Spopo_31_25670Putative folylpolyglutamate synthase
Stackebrandtia nassauensis102104Snas_1159FolC bifunctional protein
Snas_1821FolC bifunctional protein
Staphylococcus epidermidis12993SE_1338folylpolyglutamate synthase
Staphylococcus saprophyticus subsp. saprophyticus102446SSP1102folylpolyglutamate synthase
Starkeya novella14993Snov_3922FolC bifunctional protein
Streptococcus equinus12553HMPREF0819_0603bifunctional protein FolC
HMPREF0819_0702bifunctional protein FolC
Streptococcus mitis106071SM12261_0581folylpolyglutamate synthase
SM12261_0850dihydrofolate:folylpolyglutamate synthetase
Streptomyces avermitilis14893SAV5452putative folylpolyglutamate synthase
Streptomyces cattleya14057SCAT_1736putative folylpolyglutamate synthase
Streptomyces clavuligerus13307SCLAV_1780putative folylpolyglutamate synthase
SCLAV_p1539Folylpolyglutamate synthetase
Streptomyces ghanaensis15414SSFG_04758folylpolyglutamate synthase
Streptomyces mobaraensis13819H340_24420folylpolyglutamate synthase
Streptomyces pristinaespiralis13074SSDG_02772folylpolyglutamate synthase
Streptomyces purpureus13925STRPU_06_00710Putative folylpolyglutamate synthase
Streptomyces sviceus13980SSEG_04578folylpolyglutamate synthase
Streptomyces venezuelae13096SVEN_2392Dihydrofolate synthase or Folylpolyglutamate synthase
Streptosporangium roseum3776Sros_7286FolC bifunctional protein
Synechococcus elongatusSynpcc7942_0944FolC bifunctional protein
Synechocystis sp.sll1612gene:folC or dedC
Tetragenococcus halophilus12172TEH_09690folylpolyglutamate synthase
Thauera linaloolentis102519C666_02820dihydrofolate synthase/tetrahydrofolylpolyglutamate synthase
Thermanaerovibrio acidaminovoransTaci_0949FolC bifunctional protein
Thermobispora bispora14880Tbis_2472FolC bifunctional protein
Thermodesulfobium narugense100082Thena_1335FolC bifunctional protein
Thermodesulfovibrio yellowstoniiTHEYE_A0558folylpolyglutamate synthase
Thermomicrobium roseumtrd_0524folylpolyglutamate synthase
trd_A0255folylpolyglutamate synthase (folylpoly-gamma-glutamatesynthetase)
Thermomonospora curvata15933Tcur_1536FolC bifunctional protein
Thermotoga lettingae107922Tlet_1984FolC bifunctional protein
Thermotoga maritima100826TM_0166folylpolyglutamate synthase/dihydrofolate synthase
Thermotoga naphthophila104846Tnap_0796FolC bifunctional protein
Thermotoga neapolitana107923CTN_0521Folylpolyglutamate synthase/dihydrofolate synthase
Thermotoga petrophila104847Tpet_0759FolC bifunctional protein
Thermotoga thermarum107925Theth_1963FolC bifunctional protein
Thermus thermophilus101084TTHA0343folyl-polyglutamate synthetase
TTHA1340folyl-polyglutamate synthetase
Thermus thermophilus101085TT_C0975folylpolyglutamate synthase/dihydrofolate synthase
TT_C1640folylpolyglutamate synthase
Tsukamurella paurometabola16120Tpau_1469FolC bifunctional protein
Turicella otitidis106139HMPREF9719_00499FolC protein
Vibrio alginolyticus15630N646_1291folylpolyglutamate synthase/dihydrofolate synthase
Vibrio ichthyoenteri15847VII00023_13427folylpolyglutamate synthase/dihydrofolate synthase
Vibrio metschnikovii103153VIB_001697dihydrofolate synthase/folylpolyglutamate synthase
Vibrio orientalis15638VIOR3934_06279dihydrofolate synthase/folylpolyglutamate synthase
Vibrio tubiashii15644VITU9109_22965dihydrofolate synthase/folylpolyglutamate synthase
Vibrio vulnificus15645B736_04440bifunctional folylpolyglutamate synthase/ dihydrofolate synthase
Weeksella virosa16016Weevi_1305FolC bifunctional protein
Xenococcus sp.Xen7305DRAFT_00028850folylpolyglutamate synthase/dihydrofolate synthase
Xylanimonas cellulosilytica107835Xcel_1149FolC bifunctional protein
Yersinia bercovieri105717yberc0001_27460Folylpolyglutamate synthase
Yersinia rohdei105715yrohd0001_24870Folylpolyglutamate synthase
Zimmermannella faecalis15706G328_06350hypothetical protein
Zymomonas mobilis subsp. pomaceae13757Zymop_0637FolC bifunctional protein